How It Works

Delivery Application – WilloMD™

The WilloMD™ is the initial performance device in the Physician's Technology product suite. The device that is equipped with the NINS® treatment operating system that provides the Veriscription™ to the device.

  • Applying the WilloMD™ to the skin surface sparks receptor sites that results in “biomodulation” and a sequence of well known and extensively reported biological and physiological events. Pain relief is achieved, mobility improved and wound healing is accelerated.
  • A review of the sequence of Bio-Physiological effects is illustrated in Fig. 1 and Table 2 below.

The Science:

For many years photo energy and thermal energy have been employed to help relieve pain and to promote healing. The literature is replete with studies and reports regarding the use of these energies and the biological and physiologic effect on living organisms. Below we report the bio-physiologic sequences that are known to occur in the body with application of these energies utilized in the WilloMD™.

It is most important to note, that what distinguishes the WilloMD™ as being uniquely different (Woolston) than any other device or method, is the patented platform that consists of The NINS® operating system AND the proprietary Veriscription™ algorithm. The result is:

  • Treatment results that are highly effective (> 83%)
  • Prevention of tachyphylaxis (adaptation by the body), which insures continued effective response to treatment.
  • No adverse side effects.

knee illustration

Table 1: Bio-Physiological effects produced with application of the WilloMD™

Event Effect Result
Release of Nitric Oxide Local Vasodialation
  • Increased blood flow
  • Pain Reduction
  • Increased delivery of cellular nutrients
  • Accelerated removal of:
    • Toxins
    • Cellular debris
    • Edema (swelling)
      • Improved Mobility
      • Pain reduction
      • Reduced Stiffness
      • Enhanced performance
Release of the body’s own "morphine like" substances ↑endorphins
↑enkephalin
↑dynorphin 		Pain Relief
Heat > 104 degrees Heat receptor TRPV1 blocks P2X3 pain receptor. Pain Relief ( above and beyond comfort and placebo effect)
Effect on nerves ↑perception threshold of sensory nerves Pain Relief;
Effect on nerves ↓nerve conduction velocity Pain Relief
Attracts and accelerates migration of inflammatory cells ↑Macrophages Physiologic wound debridement - increased phagocytosis
Attracts and accelerates migration of reparative cells ↑Fibroblasts Accelerated:
  • Deposition of Fibrin
  • Synthesis of Collagen
  • Rapid increase in wound tensile strength
  • Accelerated wound healing
  • Reduction in wound infection rate


References:i

Abergel RP, et al, Control of connective tissue metabolism by laser: recent developments and future prospects. J Dermatol Surg Oncol. 1987: 13:127-33.

Balboni GC, Brandi Ml, Zonefrati R, Repice F, Effects of He-Ne/I.R. laser irradiation on two lines of normal human fibroblasts in vitro. Arch Ital Anat Embrio. 1986; 91: 179-88.

Basford JR, Low energy laser therapy: controversies and new research findings. Lasers Surg Med. 1989; 9:1-

Bosatra M, Jucci A, Olliaro P, et al, In vitro fibroblast and dermis fibroblast activation by laser irradiation at low energy; an electron microscopic study. Dermatologica. 1984; 168: 157-162.

Braukus, Michael. NASA Space Technology Shines Light on Healing. NASA News, National Aeronautics and Space Administration, Marshall Space Flight Center, Huntsville, Alabama, December 18, 2000.

Brink, EE and Mackel, RG, Time course of action potentials recorded from single human afferents, Brain, Vol. 116, No. 2, 415-432, 1993.

Chow, RT, Johnson, MI, Lopes-Martins, R, Bjordal, JM, Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials. The Lancet, Vol. 374 No. 9705 pp 1897-1908.

Crow JP, Beckman JS. Raactions between NO, O2, and peroxynitrite: Footprints of peroxynitrite in vivo. Adv. Pharmacol. 1995:34:17-43.

Cunningham LW, Frederiksen DW, Structural and contractile proteins. Part A. Extracelluar matrix. Methods Enzymol. 1982: Vol 82, New York, Academic Press.

Goldman JA, Chipella J, Casey H, et al, Laser therapy of rheumatoid arthritis. Lasers Surg Med. 1980. 1:93-101.

Hamilton , Lyla D., Shedding some light on pain relief Boulder County Business Report, May 25, 2007.

Horwitz LR, Burke TJ, Carnegie D., Augmentation of wound healing using monochromatic infrared energy. Exploration of a new technology for wound management. Advances in Wound Care 1999 Jan-Feb; 12(1):35-40.

King, Brian, Heat “blocks body’s pain signals. http://news.bbc.co.uk/2/hi/health/5144864, 5 July 2006.

King, Clelland, Knowles, Jackson, Effect of helium-neon laser auriculotherapy on experimental pain threshold. Physical Therapy. 1990; 70:1:24-30.

Lam TS, Abergel RP, Dwyer RM, Biological effects of laser: Stimulation of collagen production by low energy lasers in human fibroblast cultures. J Am Soc Laser Med Surg. 1983; 3:189

Lam TS, Abergel RP, Meeker CA, et al, Laser stimulation of collagen synthesis in human skin fibroblast cultures. Laser Life Sci. 1986; 1:1:61-77.

Lyons RF, Abergel R, White R, et al, Biostimulation of wound healing in vivo by a helium-neon laser. Annals of Plastic surgery. 1987; 18:1: 47-50.

Olson JE, Schimmerling W, Tobias CA, Laser action spectrum of reduced excitability in nerve cells. Brain Res. 1981; 204:436-440.

Santana-Blank LA, Rodriguez-Santana E, Santana-Rodriguez KE, Photo-infrared pulsed bio-modulation (PIPBM): a novel mechanism for the enhancement of physiologically reparative responses. Photomed Laser Surg. 2005 Aug;23(4):416-24.

Shapiro RS, Stockard HE, Diminution of electroencephalographic muscle tremor artifact, Journal of Intensive Care Medicine. 1989; 17:3:5.

Walker JB, Relief from chronic pain by low power laser irradiation. Neurosci Lett. 1983; 43:339-344.

Woolston, C. A dim view of Light Relief’s Claims to relieve pain with LEDs, Los Angeles Times, February 23, 2009.

Weidner,C. Schmidt, R. Schmelz, R, Hilliges, M , Handwerker, HO, and Torebj, HE., Time course of postexcitatory effects separates afferent human C fibre classes. Clinical Neurophysiology, 527.1, 27 June 2000.

Yew D, Pang LW, Mok Y, Au C., Stimulation of collagen formation in the intestinal anastomosis by low dose He-Ne laser. Scanning Microsc. 1989: 3:379-86.

i Citations reference both coherent and non-coherent light. The effects noted above have been reported to obtain with both photo-energy sources.

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